PE-22-28 is a short 7-amino-acid fragment of spadin, a natural brain peptide. It blocks the TREK-1 potassium channel, a target linked to mood, and is used in mood, stress and brain-recovery research as a smaller, stronger version of the parent peptide.
PE-22-28 is studied for mood-related and neurogenesis effects in laboratory models, with the defining study reporting sub-nanomolar TREK-1 blockade and a longer window of action than spadin itself (Djillani et al., 2017, Frontiers in Pharmacology).
Research Applications
- Studied in mood and depression research models
- Relevant in research on neurogenesis and synapse formation
- Examined in stroke recovery and neuroprotection studies
- Applied in TREK-1 channel electrophysiology work
Supplied as a lyophilized powder for stability.
See also: Semax 10 mg, Selank 10 mg, and Cerebrolysin 30 mg.
Scientific Background
TREK-1 is a two-pore-domain potassium (K2P) channel that helps set the resting membrane potential of neurons and is enriched in the prefrontal cortex, hippocampus, and dorsal raphe. Mice lacking the channel show a distinctive behavioural phenotype, making TREK-1 a target of wide interest in mood research.
Spadin, a peptide released from the sortilin propeptide, was identified as a natural TREK-1 blocker with rapid effects on hippocampal neurogenesis and CREB phosphorylation in mouse models. Its activity in vivo lasted roughly seven hours, prompting a search for shorter analogs.
PE-22-28 emerged from that work: the seven-residue fragment GVSWGLR kept the channel-blocking action of the parent, bound TREK-1 with far higher affinity (IC50 about 0.12 nM versus 40-60 nM for spadin), and stayed active for up to 23 hours in vivo.
PE-22-28 Structure
Peptide Class: Synthetic spadin fragment (sortilin-derived heptapeptide)
Amino Acid Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR)
Molecular Formula: C₃₅H₅₅N₁₁O₉
Molecular Weight: 773.9 g/mol
CAS Number: 1801959-12-5
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