Abaloparatide is a synthetic peptide built from 34 amino acids, designed to mirror the active front portion of parathyroid hormone-related protein (PTHrP 1-34). It is best known in research for studying the PTH1R receptor, and what sets it apart is how it is engineered to favor one particular active state of that receptor.
It has a solid research base as a reference compound for PTH-family analog work, with published studies looking at how it engages the receptor (Hattersley et al., 2016, Endocrinology). That is why labs reach for it when comparing engineered PTHrP variants.
Research Applications
- PTH1R receptor pharmacology research
- Bone-tissue research models
- Structure-activity studies
- PTHrP analog comparison work
Supplied as a lyophilized powder for stability.
See also: Crystagen 20 mg, Cartalax 20 mg, and Epitalon.
Scientific Background
Parathyroid hormone-related protein (PTHrP) and parathyroid hormone (PTH) share an N-terminal region that activates the PTH1R receptor on osteoblasts and chondrocytes. Research on PTH and PTHrP analogs has long focused on how distinct receptor conformations bias downstream signaling toward anabolic, transient activity rather than prolonged, resorptive responses.
Abaloparatide was designed as a PTHrP (1-34) analog with targeted substitutions that increase selectivity for the transient RG conformation of PTH1R. Receptor pharmacology studies report shorter cAMP signaling durations relative to parathyroid hormone (1-34), and bone-tissue research models describe a profile favoring osteoblast-driven matrix formation over sustained osteoclast activation.
This combination of receptor-conformation selectivity and bone-tissue research output has made abaloparatide a frequently cited research tool in PTH1R pharmacology, osteoblast biology, and orthopedic cellular-signaling investigations.
Abaloparatide Structure
Peptide Class: Synthetic PTHrP (1-34) analog
Amino Acid Length: 34 residues
Molecular Formula: C₁₇₄H₃₀₀N₅₆O₄₉
Molecular Weight: ~3961 g/mol
CAS Number: 247062-33-5
Common Identifiers: Abaloparatide, BA058, PTHrP (1-34) analog
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