Epitalon

Epitalon is a synthetic bioregulator peptide built from just four amino acids in the sequence Ala-Glu-Asp-Gly (you may also see it written as Epithalon or the Khavinson tetrapeptide AEDG). It’s best known in research circles for its links to pineal-gland signaling and telomere biology, which is the trait that makes it stand out from most other short peptides.

It also carries a real research footprint, with foundational lab work tracing back decades (Khavinson et al., 2003, Bull Exp Biol Med). That history is why it keeps appearing in studies on aging-related cellular models.

Research Applications

• Pineal-gland signaling research
• Telomere-biology studies
• Gene-expression research models
• Age-related cellular research

Supplied as a lyophilized powder for stability.

See also: Pinealon 20 mg, Cartalax 20 mg, and FOXO4-DRI.

Scientific Background

The concept of peptide bioregulators emerged from research at the Saint Petersburg Institute of Bioregulation and Gerontology, where short peptides were proposed as tissue-specific signaling molecules capable of modulating gene expression and cellular homeostasis. Epitalon was designed as a synthetic analog of the pineal preparation epithalamin, with the goal of reproducing pineal-tropic regulatory activity using a defined tetrapeptide.

Subsequent studies demonstrated that the AEDG sequence can interact with chromatin-associated structures and influence the transcription of telomerase and other genes linked to cellular renewal. These observations placed Epitalon at the intersection of telomere biology, pineal endocrinology, and circadian regulation.

Its sustained presence in biogerontology research reflects continued interest in compact peptide bioregulators that modulate age-related transcriptional programs through pineal-tropic and chromatin-level mechanisms.

Epitalon Structure

Peptide Class: Synthetic pineal-tropic tetrapeptide bioregulator
Amino Acid Sequence: Ala-Glu-Asp-Gly (AEDG)
Molecular Formula: C₁₄H₂₂N₄O₉
Molecular Weight: ~390.4 g/mol
CAS Number: 307297-39-8
Common Identifiers: Epitalon, Epithalon, Khavinson tetrapeptide AEDG

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