Semaglutide is a lab-made GLP-1 analog built from a 31-amino-acid chain with an attached fatty acid that lets it stick to albumin and stay around longer. It is best known in research for its strong, selective binding to the GLP-1 receptor, and that long-acting design is what sets it apart from natural GLP-1.
It also has a solid research foundation, with work mapping how its structure drives receptor activity and extended action (Lau et al., 2015, Journal of Medicinal Chemistry). That makes it a common reference compound in incretin-pathway studies.
Research Applications
- GLP-1 receptor signaling research
- Incretin-pathway study models
- Metabolic and glucose research
- Long-acting peptide design studies
Supplied as a lyophilized powder for stability.
See also: Tirzepatide, Retatrutide, and Cagrilintide.
$21
Semaglutide Structure
Peptide Class: Synthetic acylated GLP-1 receptor agonist
Residue Count: 31 amino acids
Key Modifications: Aib at position 8, C18 fatty diacid attached via γGlu-2xOEG linker at Lys26, Arg substitution at position 34
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: ~4113.6 g/mol
CAS Number: 910463-68-2
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