Semax is a synthetic peptide built from a small seven-amino-acid fragment of the natural ACTH hormone, tweaked so it keeps the brain-signaling side without the hormone effects. It’s best known in cognitive and neuroscience research, and its stripped-down design is what sets it apart.
It also sits on a solid research base, with work exploring how it acts on nerve-cell signaling and brain-derived factors (Dolotov et al., 2006, J Neurochem). That history is why it turns up so often as a reference peptide in lab studies.
Research Applications
- Cognitive and memory research
- Neuroprotection study models
- Nerve-cell signaling research
- Brain-derived factor studies
Supplied as a lyophilized powder for stability.
See also: Selank 10 mg, Adamax 10 mg, and Pinealon 20 mg.
Scientific Background
The regulation of neural plasticity and survival is essential for recovery from brain cellular-stress models and for maintaining cognitive health during aging. Neuropeptides derived from ACTH have long been recognized for their extra-hormonal effects on the brain, particularly regarding alertness, attention, and memory.
Semax was developed to stabilize these effects, creating a longer-lasting analog that could be studied for its neurotrophic and cognitive properties. Research has since expanded from its original focus on acute cerebrovascular events to broader applications in neurobiology, including its influence on gene expression and neurotransmitter balance.
Because Semax demonstrates measurable activity at low concentrations and shows favorable stability across experimental systems, it has become a reference molecule within the ACTH-analogue research framework and a frequent comparator in studies of related synthetic neuropeptides.
Semax Structure
Peptide Class: Synthetic heptapeptide (ACTH(4-10) analog)
Amino Acid Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
Molecular Formula: C₃₇H₅₁N₉O₁₀S
Molecular Weight: 813.9 g/mol
CAS Number: 80714-61-0
PubChem CID: 122130
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