Thymosin Alpha-1

Thymosin Alpha-1 is a synthetic peptide built from 28 amino acids with an acetyl cap on its front end. It is best known in research for immune-signalling studies, and what makes it stand out is that it was never designed from scratch. It is the front section of a larger natural protein called prothymosin alpha, cut free by an enzyme and rebuilt synthetically.

It carries one of the longest research records of any short peptide, beginning with its isolation and sequencing from calf thymus tissue (Goldstein et al., 1977, PNAS). That history is why it turns up often as a reference compound in this field.

Research Applications

• Dendritic-cell maturation research
• Toll-like receptor signalling studies
• T-cell differentiation research models
• Immune-tolerance and regulatory pathways

Supplied as a lyophilized powder for stability.

See also: Thymogen, KPV, and Epitalon.

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Thymosin Alpha-1 Structure

Peptide Class: Synthetic thymic peptide, N-terminal fragment of prothymosin alpha
Amino Acid Sequence: Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN
Residues: 28 (N-terminally acetylated)
Molecular Formula: C₁₂₉H₂₁₅N₃₃O₅₅
Molecular Weight: ~3108.3 g/mol
CAS Number: 62304-98-7
Synonyms: Tα1, TA1, thymalfasin

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