Adipotide (FTPP) is a lab-made peptide mimic built as a two-part molecule, joining a fat-tissue homing sequence to a cell-disrupting segment with a small linker. It is best known in research for its targeted, address-and-payload design, which is what makes it stand out from simpler peptides.
It also has a research base, with lab work exploring how its homing piece interacts with receptors like prohibitin and annexin-A2 (Salameh et al., 2016, JCI Insight). That makes it a common reference compound in vascular-targeting studies.
Research Applications
- Ligand-directed vascular targeting research
- Prohibitin and annexin-A2 receptor studies
- Chimeric peptide design research
- Structure-activity laboratory models
Supplied as a lyophilized powder for stability.
See also: Tirzepatide, FOXO4-DRI, and Cagrilintide.
$21
Adipotide (FTPP) Structure
Peptide Class: Synthetic chimeric peptidomimetic with cyclic homing motif and D-stereochemistry proapoptotic effector domain
Amino Acid Sequence: Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-D(Lys-Leu-Ala-Lys-Leu-Ala-Lys)₂
Sequence Designation: CKGGRAKDC-GG-D(KLAKLAK)₂
Key Modification: Cyclic disulfide bridge in CKGGRAKDC homing motif; D-amino-acid stereochemistry in (KLAKLAK)₂ effector domain
Molecular Formula: C₁₁₁H₂₀₆N₃₆O₂₈S₂
Molecular Weight: 2557.2 g/mol
CAS Number: 859216-15-2
Synonyms: Fat-Targeted Proapoptotic Peptide (FTPP), Prohibitin-Targeting Peptide 1 (TP01)
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