FOXO4-DRI

FOXO4-DRI is a lab-made peptide built as a mirror-image (D-retro-inverso) version of part of the FOXO4 protein. It is best known in senescence and longevity research, where it is studied for how it interferes with the FOXO4-p53 protein pairing inside aged cells.

It also has a solid research footing, with work exploring its effect on senescent cells and tissue function in lab models (Baar et al., 2017, Cell). That is why it has become a go-to peptide in this corner of cellular aging research.

Research Applications

• Cellular senescence research
• FOXO4-p53 interaction studies
• Longevity and aging models
• Protein-binding disruption research

Supplied as a lyophilized powder for stability.

See also: Epitalon, NAD⁺, and SS-31.

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FOXO4-DRI Structure

Peptide Class: D-retro-inverso interfering peptide
Amino Acid Sequence: D-retro-inverso peptide derived from the FOXO4 p53-binding domain
Molecular Formula: C₂₂₈H₃₈₈N₈₆O₆₄
Molecular Weight: ~5358 g/mol
CAS Number: 2460055-10-9
Synonyms: FOXO4 D-Retro-Inverso peptide, Proxofim

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