PT-141, also called bremelanotide, is a synthetic cyclic peptide built from seven amino acids and classed as a melanocortin-receptor agonist. It is best known in research for how it engages the MC4R and MC3R receptors, and being a ring-shaped (cyclic) peptide is what sets its structure apart.
It also has a solid research base, with work exploring how it acts on melanocortin signaling pathways (Molinoff et al., 2003). That makes it a common probe compound in receptor-pharmacology studies.
Research Applications
- Melanocortin-receptor signaling research
- MC4R and MC3R receptor studies
- GPCR structure-activity research
- Central-nervous-system pharmacology models
Supplied as a lyophilized powder for stability.
See also: Melanotan 2, Melanotan 1, and Kisspeptin 10 mg.
$21
PT-141 Structure
Peptide Class: Synthetic cyclic heptapeptide research compound (melanocortin-receptor agonist)
Sequence: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH
Residue Count: 7 amino acids (cyclic via lactam bridge)
Key Structural Feature: Asp-Lys lactam cyclization with Nle4 and D-Phe7 substitutions
Molecular Formula: C₅₀H₆₈N₁₄O₁₀
Molecular Weight: ~1025.2 g/mol
CAS Number: 189691-06-3
Research Code: PT-141
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